The NoveltyTo better understand microsatellite-instable (MSI) tumours as a key to overcoming colorectal cancers (CRCs), this study shows that the i...

The NoveltyIn an international collaboration with the Department of Experimental Radiation Oncology from The University of Texas MD Anderson Cancer...

The NoveltyThis study unveils an immunotherapeutic approach to treat cancer by avoiding the phosphorylation of programmed cell death ligand 1 (PD-L1...

The NoveltyThis study provides strong evidence that glucose metabolic re-wiring may contribute to the development of acquired resistance of non-smal...

The NoveltyThis study reports a novel signalling pathway which converts IL-17-producing CD8+ T cells (Tc17) to IFN-γ producers, leading to enhanced...

The NoveltyThis study reveals the signaling pathway underlying how pridopidine acts as an agonist in promoting autophagy for neuron protection. When...

The NoveltyVia in vitro and in vivo studies, this study discloses the underlying mechanism of DNA double-strand break (DSB) repair carried out by M...

The NoveltyBased on a cohort of 105,184 participants, this study disclosed the underlying mechanisms of the comorbidity between psychiatric disorder...

The NoveltyThis study reported the pathway underlying how melatonin suppresses the metastatic potential of osteoblastic prostate cancer. The pathway...

The NoveltyThis study discovered the potential of exosomal membrane-bound PD-1 (Exo-PD-1) in enhancing the cytotoxic activity of T cells against tum...

The NoveltyUpon identifying two complex crystal structures of bacterial STING/c-di-GMP, this study reveals the precise binding mode of c-di-GMP to t...

The NoveltyBy implementing the 24-h urine creatinine excretion rate (U-CER) adjustment method, this study has successfully eliminated the paradoxic...